LOS ANGELES (AP) — Eric Hosmer singled in the go-ahead run with two outs in the sixth inning, and the San Diego Padres beat the Los Angeles Dodgers 2-1 in the series opener Monday night.

Joc Pederson bobbled the ball on Hosmer’s hit to left and couldn’t attempt a throw as Trent Grisham scored from second after Dustin May (1-1) walked him, giving the Padres a 2-1 lead.

Austin Hedges homered with two outs in the fifth to tie it at 1. It was Hedges’ third hit and first homer of the season and only the second home run given up by May.

Emilio Pagán retired Mookie Betts, Cody Bellinger and Justin Turner in order in the eighth, and the Dodgers managed just four hits. Betts, Bellinger and Turner were 1 for 4 with a strikeout each. Los Angeles was 1 for 8 with runners in scoring position.

Cal Quantrill (2-0) got the victory with three innings of relief. He allowed two hits and struck out three.

Drew Pomeranz retired the side in the ninth for his third save.

ANGELS 10, ATHLETICS 9

ANAHEIM, Calif. (AP) — Mike Trout hit two home runs, including a tiebreaking shot in the eighth inning, and Los Angeles rallied from an early five-run deficit to snap Oakland’s nine-game winning streak.

Trout’s solo drive off Yusmeiro Petit (1-1) in the eighth helped the Angels stop a three-game skid. It was the 20th multi-homer game of Trout’s career, which tied Tim Salmon and Vladimir Guerrero for the franchise record. Slumping newcomer Anthony Rendon also homered for the Angels.

Los Angeles trailed 9-4 in the fourth when Trout began the rally with a two-run drive into the Angels’ bullpen in left field. Shohei Ohtani had an RBI double in the inning to bring them to 9-7 and then tied it with a two-run homer to center in the sixth.

Noe Ramirez, Keynan Middleton, Felix Peña (1-0) and Ty Buttrey held Oakland scoreless. Buttrey earned his second save.

Matt Chapman homered twice and tied a career-high with six RBIs for AL West-leading Oakland.

ASTROS 6, GIANTS 4

HOUSTON (AP) — Lance McCullers Jr. pitched no-hit ball into the seventh inning, Michael Brantley and Carlos Correa drove in two runs each and Houston snapped a five-game skid.

McCullers (2-1) bounced back from one of the worst performances of his career with a gem, allowing one hit and striking out five in seven scoreless innings. The 26-year-old tied a career-high by allowing eight runs in just 3 2/3 innings of a 14-7 loss at Arizona his last time out.

His only hit allowed Monday came when Donovan Solano extended his MLB-best hitting streak to 15 games with a double in the seventh.

San Francisco rookie starter Logan Webb (1-1) allowed four hits and five runs — only two earned because of two errors — in 3 1/3 innings.

NATIONALS 16, METS 4

NEW YORK (AP) — Asdrubal Cabrera went 4 for 4 with two homers, two doubles and five RBIs, tormenting his former team again as Washington routed New York.

Juan Soto and Trea Turner homered in the third inning for the Nationals, who scored just 11 runs in their previous five games.

Cabrera, who played in 374 games for the Mets from 2016-18, became the first player to go 4 for 4 with four extra-base hits against a former team since Johnny Cooney of the Brooklyn Dodgers did it versus the Boston Bees in 1937, according to STATS.

Cabrera is batting .452 with three homers and 11 RBIs in eight games against New York since Washington signed him last August.

Soto launched a drive that landed beyond the Mets’ home run apple in center field and was projected at a career-long 463 feet. He also singled and hit an RBI double that sparked a seven-run fifth.

Patrick Corbin (2-0) cruised to the win. Steven Matz (0-3) was hammered for a career-worst eight earned runs over 4 1/3 innings.

PHILLIES 13, BRAVES 8

PHILADELPHIA (AP) — Didi Gregorius hit a grand slam, Bryce Harper blasted a three-run shot and Philadelphia got Aaron Nola his first win in nearly a year.

Nola (1-1) allowed one run, two hits and struck out 10 in eight innings. The ace right-hander was 0-5 in nine starts since his last win at Boston on August 20, 2019.

Roman Quinn, Jean Segura and J.T. Realmuto added solo shots for Philadelphia, which bounced back after getting swept in Sunday’s doubleheader to earn a split of the four-game series.

Braves lefty Sean Newcomb (0-2) allowed eight runs in 1 1/3 innings.

RAYS 8, RED SOX 7

BOSTON (AP) — Kevin Kiermaier hit a tiebreaking, two-run double in the seventh inning, Manuel Margot had four hits and Tampa Bay beat Boston.

Kiermaier’s opposite-field line drive off reliever Jeffrey Springs (0-1) rolled all the way to the wall in left-center field. Yoshi Tsutsugo and Margot scored after both singled to start the inning. Kiermaier had three RBIs.

Tampa Bay has won four of five after taking three of four against the New York Yankees at home prior to this season-high 10-game road trip.

Aaron Loup (1-0) struck out three in a scoreless inning, and Andrew Kittredge recorded the final two outs for his first career save.

TWINS 4, BREWERS 2

MILWAUKEE (AP) — Eddie Rosario hit a grand slam, Randy Dobnak pitched five strong innings and Minnesota ended a four-game skid.

Dobnak (3-1) struck out three, allowed four hits, walked one and retired his last eight batters to continue his hot start to the season.

Keston Hiura homered and Orlando Arcia hit an RBI double for the Brewers. Adrian Houser (1-1) pitched five innings and gave up only those four runs on Rosario’s grand slam.

DIAMONDBACKS 12, ROCKIES 8

DENVER (AP) — Kole Calhoun hit a leadoff homer and a two-run double to lead Arizona’s 18-hit outburst in Colorado.

David Peralta and Ketel Marte got four hits each for the Diamondbacks. Alex Young (1-0) worked two innings of relief and Archie Bradley earned his fourth save.

Rockies outfielder Charlie Blackmon had four singles to extend his hitting streak to 14 games. He has 10 multi-hit games in that stretch, including the last five to raise his batting average to .484, tops in baseball. Blackmon has 12 hits in his last 15 at-bats.

Nolan Arenado also had four hits and Trevor Story homered for Colorado.

Calhoun set the tone with a leadoff homer against Jon Gray (0-2) and added a two-run double in a three-run seventh that gave Arizona a four-run lead.

TIGERS 5, WHITE SOX 1

DETROIT (AP) — JaCoby Jones hit an inside-the-park home run and Detroit breezed past Chicago for its fourth straight victory.

Niko Goodrum homered and had four hits for the Tigers, who handed the White Sox their fifth loss in six games. It wasn’t all good news for Detroit, though. First baseman C.J. Cron exited with a left knee injury.

White Sox slugger Jose Abreu came up limping after grounding out in the eighth and left the game as well.

The Tigers improved to 9-5 on the year after losing 114 games in 2019.

Michael Fulmer pitched three scoreless innings for Detroit, and Daniel Norris (1-1) worked two.

Dallas Keuchel (2-2) allowed three runs and six hits in six innings.

MARINERS 10, RANGERS 2

ARLINGTON, Texas (AP) — Kyle Seager hit a grand slam, Kyle Lewis and Dylan Moore also homered and Seattle won its first game at the new Texas ballpark, snapping the Rangers’ three-game winning streak.

Lewis put the Mariners up 4-2 with a three-run shot in the fifth inning off Kyle Gibson (0-2). Seager added his fifth career slam an inning later.

Justin Dunn (1-1) limited Texas to two runs over six innings for his first big-league victory.

With the retractable roof opened at Globe Life Field during a game for the first time, the Mariners’ three homers were only one fewer than opponents had hit overall in the first eight games there.

Their 10 runs were the most by any team — only twice before had both teams even combined for 10 runs in a game.