Top 25 College Hoops Picks Against the Spread – Wednesday, January 22

Published 12:11 am Wednesday, January 22, 2025

There are five games featuring a ranked team on Wednesday’s college basketball slate. Below, we offer against-the-spread picks for each contest.

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AP Top 25 Picks ATS Today

No. 7 Houston Cougars vs. Utah Utes

Spread Prediction

  • Computer Prediction: Houston 79, Utah 62
  • Projected Favorite: Houston by 17.6 points
  • Pick ATS: Utah (+19.5)

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Bet on the Houston-Utah spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 6:00 PM ET
  • Location: Houston, Texas
  • Venue: Fertitta Center
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

South Carolina Gamecocks vs. No. 5 Florida Gators

Spread Prediction

  • Computer Prediction: Florida 78, South Carolina 68
  • Projected Favorite: Florida by 10.4 points
  • Pick ATS: South Carolina (+10.5)

Bet on the South Carolina-Florida spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: Columbia, South Carolina
  • Venue: Colonial Life Arena
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

TCU Horned Frogs vs. No. 12 Kansas Jayhawks

Spread Prediction

  • Computer Prediction: Kansas 71, TCU 67
  • Projected Favorite: Kansas by 4.5 points
  • Pick ATS: TCU (+6.5)

Bet on the TCU-Kansas spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: Fort Worth, Texas
  • Venue: Ed and Rae Schollmaier Arena
  • TV Channel: ESPN2
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 20 St. John’s Red Storm vs. Xavier Musketeers

Spread Prediction

  • Computer Prediction: St. John’s 77, Xavier 69
  • Projected Favorite: St. John’s by 8.1 points
  • Pick ATS: Xavier (+8.5)

Bet on the St. John’s-Xavier spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: New York City, New York
  • Venue: Madison Square Garden
  • TV Channel: Fox Sports 1
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 16 Ole Miss Rebels vs. No. 13 Texas A&M Aggies

Spread Prediction

  • Computer Prediction: Ole Miss 73, Texas A&M 70
  • Projected Favorite: Ole Miss by 2.8 points
  • Pick ATS: Texas A&M (+3.5)

Bet on the Ole Miss-Texas A&M spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:00 PM ET
  • Location: Oxford, Mississippi
  • Venue: The Sandy and John Black Pavilion at Ole Miss
  • TV Channel: ESPN2
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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